Correlation Between Cystatin-C and Interleukin-34 Expression Detection and Post-Stroke Cognitive Impairment

Xinlei Wang; Weina Guo; Jinye Zhao; Jing Zhao; Jing Wei

doi:10.29271/jcpsp.2025.08.1065

Author(s)

Xinlei Wang Department of Internal Medicine-Neurology, Baoding No.1 Central Hospital,Hebei,China

Weina Guo Department of Internal Medicine-Neurology, Baoding No.1 Central Hospital,Hebei,China

Jinye Zhao Department of Internal Medicine-Neurology, Baoding No.1 Central Hospital,Hebei,China

Jing Zhao Department of Internal Medicine-Neurology, Baoding No.1 Central Hospital,Hebei,China

Jing Wei Department of Internal Medicine-Neurology, Baoding No.1 Central Hospital,Hebei,China

Abstract

The aim of this study was to explore the relationship between the expression levels of Cystatin-C (Cys-C) and Interleukin-34 (IL-34) and cognitive impairment following a stroke. It was a retrospective study carried out from May 2022 to May 2024. Stroke patients were selected as research subjects; 109 patients had cognitive impairment (PSCI group), while 191 patients did not have cognitive impairment (non-PSCI group). The di erences in Cys-C and IL-34 levels between the two groups and the correlation between Cys-C, IL-34, and post-stroke cognitive impairment were compared. There was a statistically signi cant di erence in the levels of Cys-C and IL-34 between the two groups. The correlation analysis showed a signi cant correlation between Cys-C (r = 0.192, p = 0.001) and IL-34 (r = 0.393, p <0.001) levels and cognitive dysfunction. Multivariate analysis showed that Cys-C (OR = 6.768, p = 0.016) and IL-34 (OR = 0.049, p = 0.002) were risk factors for cognitive dysfunction in patients. Cys-C and IL-34 expressions are signi cantly correlated with post-stroke cognitive impairment.

Publication Details

Page(s) 1065-1067

DOI 10.29271/jcpsp.2025.08.1065

Published Journal: Journal of the College of Physicians and Surgeons Pakistan, Volume: 35, Issue: 08, Year: 2025

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Keywords

Stroke, Cystatin-C, Cognitive impairment, Interleukin-34

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