No Detail Found!

Inflammatory bowel disease in pediatrics

Author(s)
Darmadi Darmadi Department of Internal Medicine and Gastroenterology, Faculty of Medicine,Universitas Sumatera Utara, Medan, Indonesia
Riska Habriel Ruslie Department of Pediatrics, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Abstract
Inflammatory bowel disease (IBD) comprises of Crohn's disease (CD) and ulcerative colitis (UC). This is a chronic inflammation involving gastrointestinal tract. The prevalence of IBD is increasing recently. Approximately, 25% of all IBD cases develop during childhood. Intrinsic and extrinsic factors play important role in the pathogenesis of IBD. Mild form of IBD is more common in children with symptoms ranging from weight loss, rectal bleeding, diarrhea, and abdominal pain. Diagnosis is established based on history, physical examination, laboratory examination, imaging, endoscopy and colonoscopy, and ultimately, histopathology examination. Management includes utilization of aminosalicylates, corticosteroids, immunomodulators, and biologic agents. Nutritional support, psychosocial approach and surgical approach are other therapeutic options. The complications may occur such as micronutrient deficiency, growth failure, increased risk of malignancies, and psychiatric disorders. Routine monitoring of disease progress and growth achievement is mandatory in the management of IBD. 
Publication Details
Page(s) 269-275
DOI DOI not available
Published Journal: Rawal Medical Journal, Volume: 48, Issue: 1, Year: 2023

Request the full text from PASTIC

Keywords
Colitis, Inflammatory Bowel Disease, Crohn’s Disease, Pediatric.
References
Shapiro JM,Subedi S,LeLeiko NS .2016 .Inflammatory bowel disease. Pediatr Rev, 37 : 337-47.
Roberts SE,Thorne K,Broekaert I,Benninga MA,Dolinsek J,Mas E .2020 .A systematic review and metaanalysis of pediatric inflammatory bowel disease incidence and prevalence across Europe. J Crohns Colitis, 14 : 1119-48.
Ruslie RH,Darmadi D. .2020 .Administration of neem (Azadirachta indica A. Juss) leaf extract decreases TNF-α and IL-6 expressions in dextran sodium sulfate-induced colitis in rats. J Adv Vet Anim Res, 7 : 744-9.
Ruslie RH,Darmadi D,Siregar GA .2020 .The effect of neem (Azadirachta indica) leaf extracts on interleukin-10 expression and histological score in dextran sodium sulfate-induced colitis mice. Open Access Maced J Med Sci, 8 : 578-82.
Benchimol EI,Fortinsky KJ,Gozdyra P,Van den Heuvel M,Van Limbergen J,Griffiths AM .2011 .Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis, 17 : 423-39.
Diefenbach KA,Breuer CK .2006 .Pediatric inflammatory bowel disease. World J Gastroenterol, 12 : 3204-12.
Rosen MJ,Dhawan A,Saeed SA .2015 .Inflammatory bowel disease in children and adolescents. JAMA Pediatr, 169 : 1053-60.
Darmadi D,Ruslie RH .2021 .Immunological aspect in inflammatory bowel disease. Open Access Maced J Med Sci, 9 : 708-11.
Siregar GA,Darmadi D,Ruslie RH .2021 .The role of epigenetic mechanism in the pathogenesis of inflammatory bowel disease. Open Access Maced J Med Sci, 9 : 436-40.
Siregar GA,Darmadi D,Ruslie RH .2021 .The role of ethnicity in inflammatory bowel disease. Open Access Maced J Med Sci, 9 : 342-6.
Poddighe D,Telman A,Tuleutayev E,Ibrayeva A .2020 .Pediatric ulcerative colitis in Kazakhstan: first case series from Central Asia and current clinical management. Gastroenterol Insights, 11 : 27-35.
Senbanjo I,Akinola A,Kumolu-Johnson T,Igbekoyi O,Oshikoya K. .2020 .Inflammatory bowel disease in Nigerian children: case series and management challenges. Paediatr Int Child Health, 40 : 143-7.
Working IBD .2005 .Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria. J Pediatr Gastroenterol Nutr, 41 : 1-7.
Choe JY,Choi S,Song KH,Jang H,Choi K,Yi D .2021 .Incidence and prevalence trends of pediatric inflammatory bowel disease in the Daegu-Kyungpook province from 2017 to 2020. Front Pediatr, 810173 : 810173.
Huang JG,Aw MM .2020 .Pediatric inflammatory bowel disease in Asia: epidemiology and natural history. Pediatr Neonatol, 61 : 263-71.
Olczyk M,Czkwianianc E,Socha-Banasiak A .2022 .Metabolic bone disorders in children with inflammatory bowel disease. Life, 12 : 423-8.
Hasosah M,Alhashmi W,Abualsaud R,Alamoudi A,Aljawad A,Tunkar M .2022 .Environmental risk factors for childhood inflammatory bowel disease: a multicenter case-control study. Children, 9 : 438-43.
Day AS,Ledder O,Leach ST,Lemberg DA .2012 .Crohn's and colitis in children and adolescents. World J gastroenterol, 18 : 5862-9.
Hayes P,Dhillon S,O'Neill K,Thoeni C,Hui KY,Elkadri A .2015 .Defects in NADPH oxidase genes NOX1 and DUOX2 in very early onset inflammatory bowel disease. Cell Mol Gastroenterol Hepatol, 1 : 489-502.
Cutler DJ,Zwick ME,Okou DT,Prahalad S,Walters T,Guthery SL .2015 .Dissecting allele architecture of early onset IBD using high-density genotyping. PLoS One, 10 : e0128074.
Shouval DS,Rufo PA .2017 .The role of environmental factors in the pathogenesis of inflammatory bowel diseases: a review. JAMA Pediatr, 171 : 999-1005.
Sledzinska K,Landowski P,Zmijewski MA,Kaminska B,Kowalski K,Liberek A .2022 .Diet, sun, physical activity and vitamin d status in children with inflammatory bowel disease. Nutrients, 14 : 32.
Nambu R,Hagiwara S,Kubota M,Kagimoto S M .2016 .Difference between early onset and late-onset pediatric ulcerative colitis. Pediatr Int, 58 : 862-6.
Gasparetto M,Guariso G .2014 .Crohn's disease and growth deficiency in children and adolescents. World J Gastroenterol, 20 : 13219-33.
Newton L,Delbecque L,Coskun U,Symonds T,Clegg J,Hunter T. .2021 .A qualitative study to explore symptoms and impacts of pediatric and adolescent crohn's disease from patient and caregiver perspective. J Patient Rep Outcomes, 5 : 49-53.
Gerenli N,Sozeri B,Kalin S,Kirmizibekmez H,Celtik C .2021 .Sacroiliac joint involvement in children with inflammatory bowel diseases. North Clin Istanb, 9 : 57-63.
Bousvaros A,Antonioli DA,Colletti RB,Dubinsky MC .2007 .Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America. J Pediatr Gastroenterol Nutr, 44 : 653-74.
Turner D,Ruemmele FM,Orlanski-Meyer E,Griffiths AM,de Carpi JM,Bronsky J .2018 .Management of paediatric colitis, part 1: ambulatory care-an evidencebased guideline from European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr, 67 : 257-91.
Kelsen JR,Sullivan KE,Rabizadeh S,Singh N,Snapper S,Elkadri A .2020 .North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition position paper on the evaluation and management for patients with very early-onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 70 : 389-403.
0

Citations

0

Downloads

49

Views