Carbon Paste Electrode Modified with PMBP: A Sensitive Sensor for Electrochemical Detection of Acetaminophen

Emi Norzehan Mohamad Mahbob,; Mohamad Syahrizal Ahmad; Illyas Md Isa; Norhayati Hashim; Anwar Ul-Hamid; Mohamad Idris Saidin; Suyanta M. Si

doi:10.52568/001439/JCSP

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Carbon Paste Electrode Modified with PMBP: A Sensitive Sensor for Electrochemical Detection of Acetaminophen

Author(s)

Emi Norzehan Mohamad Mahbob, Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia; Faculty of Applied Sciences, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Tapah Road, 35400 Perak Darul Ridzuan, Malaysia.

Mohamad Syahrizal Ahmad Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia; Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia.

Illyas Md Isa Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia; Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia.

Norhayati Hashim Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia; Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia.

Anwar Ul-Hamid Center for Engineering Research, Research Institute, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.

Mohamad Idris Saidin Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia; Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak Darul Ridzuan, Malaysia.

Suyanta M. Si Department of Chemistry Education, Faculty of Mathematics and Natural Science, Yogyakarta State University, Indonesia.

Abstract

Summary: In this present work, a sensitive electrocatalytic modified electrode based on 1-phenyl-3methyl-4-benzoyl-5-pyrazolone (PMBP)/multiwalled carbon nanotubes (MWCNT) modified carbon paste electrode (CPE) was successfully developed. Electrochemical impedance spectroscopy, square wave voltammetry, chronocoulometry and cyclic voltammetry were used in prompt to evaluate the PMBP/MWCNT/CPE electrochemical capacity in detecting acetaminophen (APAP) in 0.1 M PBS pH 6.4. Under optimized conditions, PMBP/MWCNT/CPE displayed a well-defined electrocatalytic activity towards APAP oxidation in the linear responses which range from 1 µM to 1 mM (R2 = 0.991) with the LOD obtained at 0.245 µM while LOQ 0.816 µM. The presence of excess (10-fold and 25fold) interferents such as sucrose, fructose, glucose, sodium chloride, sodium sulphate, potassium nitrate, lysine, potassium chloride and magnesium chloride as interferents was insignificant. The results presented in this study provide new perspectives on PMBP as a potential nanomaterial in the development of APAP sensors. As a conclusion, the PMBP/MWCNT/CPE revealed good stability, reproducibility, and repeatability, and was discovered to be relevant for usage in the pharmaceutical samples with satisfactory performance.

Publication Details

Page(s) 130-145

DOI 10.52568/001439/JCSP

Published Journal: Journal of Chemical Society of Pakistan, Volume: 46, Issue: 1, Year: 2024

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Keywords

Acetaminophen, Electrochemical Impedance Spectroscopy, Multiwalled carbon nanotubes, Chronocoulometry, Pyrazolone, voltammetry

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