No Detail Found!

Potential preservatives interaction in pharmaceutical formulations.

Author(s)
Ziyaur Rahman Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard New Delhi, India
Kanchan Kohli Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard New Delhi, India
Hardarshan Singh Lanlba Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard New Delhi, India
Arvind Rathour SBMN Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, India
Rakesh Pahwa SBMN Institute of Pharmaceutical Sciences and Research, Asthal Bohr, Rohtak, Haryana, India
Abstract
Pharmaceutical products contain number of excipients besides active principle, e.g. diluents, vehicles, antioxidants, chelating agent and preservative etc. Each excipient performs intended specific function. Antimicrobial preservatives are used to reduce the likelihood of microbial growth in pharmaceutical products. Preservatives interact specifically or non- specifically with either active or non active principles of formulation or in some eases both. In general interactions are antagonistic in nature. However, in some cases this interaction may synergise the preservative activity or are beneficial in some other form. This review article highlights documented interactions both synergistic and antagonistic in nature between preservatives and other components of formulation. It may also help in acquiring better understanding and appreciation of implication of adding preservative to the formulation.
Publication Details
Page(s) 25-28
DOI DOI not available
Published Journal: Hamdard Medicus, Volume: 48, Issue: 1, Year: 2005

Request the full text from PASTIC

More from Hamdard Medicus
0

Citations

0

Downloads

65

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk