To highlight the health implications due to increasing population of stray dogs and outline the problems of post exposure prophylaxis. Design: Two case reports on rabies with failure of postexposure prophylaxis. Setting: Medical unit of the teaching hospital, Ayub Medical College, Abbottabad. Results: Both the cases developed rabies and expired despite postexposure rabies vaccination. First case presented with psychiatric features. Conclusion: Postexposure rabies vaccination should not be relied upon, in our health setup, unless its efficacy has been confirmed by measurement of protective antibody titre