Lichen sclerosus has two different faces: Western versus Eastern face

Khalifa E. Sharquie; Thamir A. Kubaisi; Inas K. Sharquie

Author(s)

Khalifa E. Sharquie Department of Dermatology, College of Medicine, University of Baghdad. Medical City Teaching Hospital, Baghdad, Iraq.

Thamir A. Kubaisi Department of Dermatology, College of Medicine, University of Anbar; Ramadi, Anbar, Iraq

Inas K. Sharquie Department of Microbiology and Immunology, College of Medicine, University of Baghdad, Baghdad, Iraq.

Abstract

Background In Western countries, lichen sclerosus is a common disease that affects commonly middle-aged females that presents most commonly as a disease of genital and anal regions in both sexes while extra-genital involvement is less frequent. Objective To record all cases of lichen sclerosus in Iraqi population as one of Middle East country and to do a full clinical evaluation and to be compared with published literature as seen in Western countries. Methods This is a cross-sectional descriptive study where all patients with lichen sclerosus were recorded during the period from 2013-2022. Full history and examination were carried out. A histopathological assessment was performed as a confirmatory test. Results All data related to 28 patients with lichen sclerosus was registered and evaluated. The age of patients has a bimodal peak in incidence from prepubertal to a postmenopausal age group and ranged from 8-63 years with a median of 40 years with 24 (85.7%) females and 4 (14.2%) males with a ratio of 6:1. The clinical features of the disease were found to be genital involvement in three (10.7%) patients, one male with follicular lesions of penis and two females with vulval involvement: one with extensive atrophy of vulva while the other with very early lesions). While 25 (89.2%) cases with extragenital sites where the trunk and limbs were the main locations but lips were affected in one female patient and in another, the ears were involved. The primary lesions in almost half of the cases were follicular whitish sclerosed macules, some with follicular plugs. These lesions over time coalesced together into larger whitish ivory leukoderma in the form of patches and plaques. The rash was localized in 22 (78.6%) cases while extensive in 5 (17.9%) patients. The lesion was asymptomatic apart from slight discomfort and itching but there was severe intractable itching in the female genitalia. The HE-stained sections showed complete atrophy of the epidermis with complete sclerosis of the dermis leaving sub-epidermal cleft. Conclusion Lichen sclerosus is a disease prevalent in females that commonly presents with extragenital whitish sclerosed leukoderma in the form of follicular macules, patches and plaques while female genital involvement is a rare presentation. The likelihood of extragenital lichen sclerosus following the Blaschko lines was pronounced.

Publication Details

Page(s) 485-492

DOI DOI not available

Published Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 2, Year: 2024

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Keywords

Middle East, Western countries, Genital disease, Lichen sclerosus, Iraqi population, Leukoderma

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