Immunoproliferative Small Intestinal Disease (IPSID)

Shahid Pervez; Khalid Mumtaz; Syed Siddiq Ullah; Nake Akhtar; Naureen Ali; Hina Aaqil

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Immunoproliferative Small Intestinal Disease (IPSID)

Author(s)

Shahid Pervez Department of Pathology, The Aga Khan University Hosptial, Karachi.Pakistan

Khalid Mumtaz Department of Medicine, The Aga Khan University Hosptial, Karachi.Pakistan

Syed Siddiq Ullah Department of Medicine, The Aga Khan University Hosptial, Karachi.Pakistan

Nake Akhtar Department of Medicine, The Aga Khan University Hosptial, Karachi.Pakistan

Naureen Ali Department of Medicine, The Aga Khan University Hosptial, Karachi.Pakistan

Hina Aaqil Department of Medicine, The Aga Khan University Hosptial, Karachi.Pakistan

Abstract

This study describes the frequency, demographics, clinical presentation, endoscopic findings, histopathological features, treatment and outcome of 'Immunoproliferative small intestinal disease' (IPSID). Archives contained a total of 27 cases of IPSID diagnosed and treated over an 18-year period. A M: F ratio of 2.4:1 was seen with a mean and median ages of 28.7 and 25 years. Most patients (68.8%) presented with abdominal pain and diarrhoea. In the majority (62.5%), duodenum was the primary site of involvement. Endoscopy showed polypoidal, raised or flat lesions. Biopsy findings included blunting or flattening of villi with dense plasma cell infiltrate and lymphoepithelial lesions. Twenty-four cases were categorized as stage A and B (benign and intermediate) and three were categorized as stage C (malignant, diffuse large B-cell lymphoma with plasmacytoid features). Stage A and B patients responded well to antibiotic treatment (tetracycline) with regression of the lesions while for stage C patients standard CHOP chemotherapy was administered.

Publication Details

Page(s) 57-58

DOI DOI not available

Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 21, Issue: 1, Year: 2011

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Keywords

Antibiotic, Lymphoma, CHOP, chemotherapy, Small Intestine, IPSID

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