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Common variable immunodeficiency associated enteropathy: A diagnostic enigma in developing countries

Author(s)
Muhammad Aftab Hassan Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan
Muhammad Hussain Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi,Pakistan
Dawood Ahmad Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi,Pakistan
Muhammad Omair Riaz Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi,Pakistan
Muhammad Zain Arshad Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi,Pakistan
Abstract
Common variable immunodefi ciency (CVID) is the most prevalent primary immunodefi ciency disorder with different phenotypes and aetiologies. It is characterised by hypogammaglobulinaemia, defects in specifi c antibody response, erroneous activation and proliferation of T cells, leading to increased risk of recurrent infections. In CVID, "Variable" refers to the heterogeneity of clinical presentations, which include recurrent infections, autoimmunity, enteropathy, and increased risk of malignancies. This wide spectrum of disease manifestations and being a diagnosis of exclusion poses a diagnostic challenge. It is pertinent to mention that CVID along with associated complications is the commonest symptomatic primary antibody defi ciency but is scarcely mentioned in local literature. The main aim of presenting this case is to impress upon the importance of systematic immunological workup in cases of suspected immunodefi ciency to prevent morbidity and mortality.
Publication Details
Page(s) 1175-1177
DOI 10.47391/JPMA.9376
Published Journal: Journal of Pakistan Medical Association, Volume: 74, Issue: 6, Year: 2024

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Keywords
Primary Immunodefi ciency, Common Variable Immunodefi ciency, Enteropathy
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