This study investigated the gender differences in persistent academic possible selves and self-esteem in university students. A sample of 176 students was collected from the University of the Punjab, Lahore, Pakistan, using a convenient sampling technique. Rosenberg's self-esteem scale (Rosenberg, 1965), and the Persistent Academic Possible Selves scale (Lee et al, 2015) were used to measure global self-esteem and students' academic possible selves respectively. Items of the measure of persistent academic possible selves include three theoretical components i.e., social identity, personal identity, and self-regulation. Results showed significant gender differences in the measures of persistent academic possible selves among university students. Moreover, female research participants had higher persistent academic possible selves based on social identity and self-regulation than male research participants. However, significant gender differences were not found in self-esteem.