No Detail Found!

Liver function tests in preeclampsia

Author(s)
Bibi Munazza Department of Physiology, Ayub Medical College,Abbottabad-Pakistan
Nuzhat Raza Department of Physiology, Ayub Medical College,Abbottabad-Pakistan
Ayesha Naureen Biochemistry,Ayub Medical College,Abbottabad-Pakistan
Shahbaz Ali Khan Pathology, Ayub Medical College, Abbottabad, Pakistan
Fozia Fatima Pathology, Ayub Medical College,Abbottabad-Pakistan
Muhammad Ayub Department of Physiology, Ayub Medical College,Abbottabad-Pakistan
Muhammad Sulaman Department of Pathology, Ayub Medical College,Abbottabad-Pakistan
Abstract
Background: Preeclampsia is a multisystem disorder that can induce damage to cardiovascular system, kidneys, brain and liver. Pregnancy-induced hypertension (PIH) is responsible for significant maternal and perinatal morbidity. This study was conducted to compare the liver function tests in preeclampsia with normal pregnancy. Methods: This study was carried out on 100 pregnant women after 20 weeks of gestation admitted in Obs/Gyn units of Ayub Teaching Hospital, Abbottabad. The subjects were divided into two groups. Group A consisted of 50 cases of preeclampsia having blood pressure ³140/90 mmHg, proteinuria in 24 hours ³300 mg and oedema; Group B had 50 normal pregnant women after 20 weeks of gestation. The data including BMI, parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin and plasma levels of liver enzymes ALT, AST and ALK were measured. Results: The mean BMI of the cases was 29.04±3.97 and that of controls was 26.54±3.11. The mean value of serum bilirubin in cases was 10.78±3.74 µmol/L and in controls it was 7.92±2.42 µmol/L (p<0.001). The mean values of enzyme ALT in cases was 55.81±31.93 U/L while in the controls it was 15.22±3.30 U/L (p<0.001). Mean serum AST in the cases was 41.34±10.76 U/L and in the controls it was 24±2.54 U/L (p<0.001). Mean ALK level of cases before delivery was 454.16±243.69 U/L, and in controls it was 181.34±66.76 U/L (p<0.001). Conclusion: Raised levels of serum bilirubin and liver enzymes ALT, AST and ALK were found in preeclampsia cases. 
Publication Details
Page(s) 3-5
DOI DOI not available
Published Journal: Journal of Ayub Medical College, Volume: 23, Issue: 4, Year: 2011

Request the full text from PASTIC

Keywords
Preeclampsia, women, Hypertension, pregnancy, liver function tests, morbidity
More from Journal of Ayub Medical College
0

Citations

0

Downloads

55

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk