Background: Molar pregnancy represents a significant burden of disease on the spectrum of Gestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. The objective of this study was to determine the frequency of GTD, and clinical presentation, management and outcome of patients with molar pregnancy. Methods: This retrospective, descriptive study was conducted at Nuclear Institute of Medicine and Radiotherapy (NIMRA), Jamshoro from 1st Jan to 31st Dec 2009. All patients diagnosed and registered as GTD were included in the study. The clinical records of all molar patients were reviewed regarding presentation, treatment, and follow-up. Results: There were a total of 167 patients presenting with different female genital tract neoplasia at NIMRA during the study period, including 39 (29.35%) cases of GTD. Hydatidiform mole was seen in 33 (84.61%) patients. Complete mole in 31 (79.48%), partial mole in 2 (5.12%) patients, invasive mole in 1 (2.56%) patient, and choriocarcinoma in 5 (12.82%) patients. The mean age of the patients was 27±9.8 years. The highest incidence was found in nulliparous and para 1. Thirty-two patients had suction evacuation and 1 patient underwent hysterectomy. Patients received chemotherapy, 17 (54.54%) patients followed protocol for 3-6 months. Conclusion: Frequency of molar pregnancy was high, more common in low-parous, poor socioeconomic class women, and usually presented late.