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A Deep Learning Framework for Multi-Drug Side Effects Prediction with Drug ChemicalSubstructure

Author(s)
Muhammad Asad Arshed Department of Software Engineering, University of Management & Technology, Lahore, Pakistan.; Department of Artificial Intelligence, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Shahzad Mumtaz Department of Data Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Omer Riaz Department of Information Technology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Waqas Sharif Department of Computer Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Abstract
Nowadays, side effects and adverse reactions of drugs are considered the major concern regarding public health. In the process of drug development, it is also considered the main cause of drug failure. Due to the major side effects, drugs are withdrawn from the market immediately. Therefore, in the drug discovery process, the prediction of side effects is a basic need to control the drug development cost and time as well as launching of an effective drug in the market in terms of patient health recovery. In this study, we have proposed a deep learning model named “DLMSE” for the prediction of multiple side effects of drugs with the chemical structure of drugs. As it is a common experience that a single drug can cause multiple side effects, that’s why we have proposed a deep learning model that can predict multiple side effects for a single drug. We have considered three side effects (Dizziness, Allergy, Headache) in this study. We have collected the drug side effects information from the SIDER database. We have achieved an accuracy of ‘0.9494’ with our multi-label classification based proposed model. The proposed model can be used in different stages of the drug development process.
Publication Details
Page(s) 19-31
DOI DOI not available
Published Journal: International Journal of Innovations in Science & Technology, Volume: 4, Issue: 1, Year: 2022

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Keywords
deep learning, PCA, Drug Chemical Structure, Multi-Label Classification, Drug Side Effect
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