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Association Between Klotho Gene Polymorphisms and Urolithiasis: A Meta-Analysis

Author(s)
Jiaxuan Qin Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China
Bo Duan Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China
Bowen Chen Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China
Jinchun Xing Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China
Tao Wang Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China
Abstract
Former studies have suggested that urolithiasis is related to Klotho gene polymorphisms. The aim of this meta-analysis was to investigate this relationship. Studies on the association between urolithiasis susceptibility and Klotho gene polymorphisms were systematically searched for in databases. Odds ratios and 95% con dence intervals were pooled as the e ect size. This meta-analysis incorporated ten articles. Klotho rs1207568 adenine (A) may be related to a decreased urolithiasis risk in Caucasians. The results showed thatKlotho rs3752472 may not be related to urolithiasis risk in the Han Asian subgroup.Klotho rs564481 may not be related to urolithiasis risk in Asians or Caucasians, and Klotho rs650439 may not be related to urolithiasis risk in Asians.
Publication Details
Page(s) 206-211
DOI 10.29271/jcpsp.2024.02.206
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 34, Issue: 2, Year: 2024

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Keywords
Meta-analysis, Urolithiasis, Single-nucleotide Polymorphism, Klotho
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