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Development of a spectroscopic method for quantitative determination of pharmaceutical preparations of vitamin-C.

Author(s)
Munawar Hussain Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Sadia Rafique Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Syed Ahmad Tirmizi Department of Chemistry, Qauid-e-Azam University, Islamabad, Pakistan
Saeed Ahmad Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Abstract
Vitamin C in aqueous solution shows concentration v s absorbance a linear relationship for dilute solutions (0.004 % to 0.005 % w/v). The pH also affects the linearity of the curve such as pH 3 is found to give a linear relationship between concentration and absorbance up to a wide range (0.001 % to 0.009 % w/v). The E (I %, 1 cm) values at pH 3 may be exploited to determine the % age purity of the vitamin C in separate vitamin C tablets or syrups. This method for the quantitatiye determination of vitamin C is more accurate, precise and applicable as compared to simple methods of UV spectrophotometry.
Publication Details
Page(s) 575-579
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 29, Issue: 6, Year: 2007

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