Solid waste is released from agricultural, industrial, commercial, mining and community activities. The management of solid waste is useful for environmental protection. Different microbial enzymes play significant role to remove toxic materials e.g., proteases are produced by several microorganisms e.g., Pseudomonas sp., Bacillus sp., Staphylococcus sp., and Aeromonas sp. can effectively degrade toxic substances of variable pH, emitted from the industries. Similarly, for the degradation of keratinous materials that are usually found in household trash, cellulase enzyme can be indulged as it activates the hydrolysis of cellulose and produces glucose and it is mainly produced by Paenibacillus sp., Bacillus sp. and Aeromonas sp. That is why; it has vital role in textile, agriculture and municipal waste management. Moreover, different bacteria, fungi and yeast are major sources of amylase production e.g., Bacillus sp. that are suitable for municipal waste bioconversion in to the fertilizers. Whereas lipase, a produce of Pseudomonas aeuriginosa, mainly act as biocatalysts that degrade the polyester waste and convert it into useful products. In short, the indulgence of biodegrading enzymatic potential of local microbial flora is an ecofriendly and economical method for better solid waste management.