BACKGROUND: Placenta is the vital, highly vascular unique organ develops from the contribution of both fetus and mother for provision of nutrients to developing fetus OBJECTIVE: To observe and compare the placental morphometric parameters in normal and preeclamptic parturients. METHODOLOGY: This cross-sectional study was conducted from August 2019 to July 2020 at Department of Anatomy of Liaquat University of Medical and Health Sciences, Jamshoro. A total of 122 placentae; 61 from controls and 61 from preeclamptic were collected from labor room immediately after delivery along with 5cm of umbilical cord attached to it. After noting demographic data and fetal weight from hospital record on predesigned proforma, morphometric examination of placenta was performed and recorded for statistical analysis on SPSS version 23. RESULTS: The mean and standard deviation of maternal age, body mass index, gestational age and parity shown in Table 1. Frequency and percentage was calculated for mode of delivery, 53 placentae were collected from normal vaginal delivery and 69 by caesarian section shown in figure 1. The shape of placenta was discoid and umbilical cord was inserted centrally in majority of cases shown in Figure 2. Placental weight when compared in two groups, was found statistically significant (p <0.01). Similarly fetal weight, diameter, thickness, volume and cotyledon count were also statistically significant, while placental coefficient and fetoplacental ratio were not statistically significant shown in Table 2. CONCLUSIONS: This study reveals significant difference in various morphometric parameters in placentae of preeclamptic in comparison of placentae from normotensive parturients.