An emerging relationship between circulating estradiol and thyroid autoimmunity in polycystic ovarian syndrome

Anam Rehman; Benash Altaf; Hira Zahid; Saba Tariq; Shireen Jawed; Sundus Tariq

doi:10.52764/jms.23.31.1.13

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An emerging relationship between circulating estradiol and thyroid autoimmunity in polycystic ovarian syndrome

Author(s)

Anam Rehman Department of Physiology, Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan

Benash Altaf Department of Physiology, Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan

Hira Zahid Department of Physiology, Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan

Saba Tariq Department of Pharmacology, University Medical and Dental College, Faisalabad, Pakistan

Shireen Jawed Department of Physiology, Aziz Fatimah Medical and Dental College, Faisalabad, Pakistan

Sundus Tariq Department of Physiology University Medical and Dental College, Faisalabad, Pakistan

Abstract

Objectives: To find an association between circulating Estradiol and thyroid autoimmunity in females with polycystic ovarian syndrome (PCOS) and its impact on their health. Materials and Methods: This study was conducted at Aziz Fatimah Medical and Dental College, after obtaining ethical approval from Institutional Ethical Committee (letter No. DME/568-19) from April to September 2017. Hundred PCOS females enrolled in the age range 17-35 years were taken who fulfilled inclusion and exclusion criteria. Blood samples were drawn and stored at Aziz Fatima Hospital, Faisalabad. All blood samples were analyzed for the levels of Estradiol, thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetra-iodothyronine (FT4), and thyroid peroxidase antibody (TPO-Ab). The data was analyzed using SPSS 23. Results: Of the total population, TPO-Ab was positive in 26% of study participants. It was observed that 64% and 40% of TPOAb positive subjects were in the Estradiol quartiles E3 and E4 respectively and none of them were found to be in E1 and E2 quartiles. We have found a significant association of the E2 with TSH, FT4, and TPO-Ab, however, no significant correlation was found between TSH and TPO-Ab. Beta coefficient (ß) of 1.006 shows that higher E2 was significantly related to higher TPO-Ab titer with p-value = 0.002. Similarly, a significant but weak positive association was found between E2 and TSH. E2 was significantly negatively associated with FT4. Conclusion: OEstradiol is positively associated with TPO antibodies and TSH and negatively associated with FT4 in PCOS patients. Our findings suggest that thyroid autoimmunity is commonly found in PCOS females.

Publication Details

Page(s) 67-71

DOI 10.52764/jms.23.31.1.13

Published Journal: Journal of Medical Science, Volume: 31, Issue: 1, Year: 2023

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Keywords

Polycystic ovarian syndrome, Oestradiol, Thyroid peroxidase antibody