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Prasugrel-related hepatotoxicity

Author(s)
Zeki Dogan Department of Cardiology, Istanbul Atlas University, School of Medicine, Medicine Hospital, Turkiye.
Mustafa Yurtdas Department of Cardiology, Istanbul Atlas University, School of Medicine, Medicine Hospital, Turkiye.
Gokhan Bektasoglu Department of Cardiology, Istanbul Atlas University, School of Medicine, Medicine Hospital, Turkiye.
Abstract
Prasugrel is usually preferred over Clopidogrel to reduce the risk of recurrent coronary thrombosis in patients who undergo percutaneous coronary interventions during an acute coronary syndrome owing to its more potent and more rapid antithrombotic activation. Little is known about Prasugrel-induced hepatotoxicity, although mild-tomoderate alanine transaminase (ALT) and gamma glutamyl transpeptidase (GGT) elevations have been noticed in postmarketing surveillance. Herein, we report the case of a patient with Prasugrel-related hepatotoxicity that was reverted after switching from Prasugrel to Ticagrelor.
Publication Details
Page(s) 2295-2297
DOI 10.47391/JPMA.3179
Published Journal: Journal of Pakistan Medical Association, Volume: 72, Issue: 11, Year: 2022

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Keywords
hepatotoxicity, Prasugrel, Percutanous coronary interventions, antiplatelet drug
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