Background: Prostate cancer is the second most common male cancer. Prostate cancer is diagnosed via a digital rectal exam, ultrasonography, and serum prostate specific antigen. Dr. Donald Gleason devised a prostate cancer grading system over 50 years ago. This system is still viable with modifications. The ISUP updated in 2005 and 2015. Gleason score and prognosis in prostatectomy stuff Gleason score, tumor volume, and tumor laterality were compared. nephroscopy and prostate Method: The study comprised 42 men with biopsy and prostatectomy materials. Gleason's grade. The new method graded tumors. Between october2019 and October 2021, 42 individuals with prostate cancer were needle biopsy diagnosed and treated with RP. Tumor volume was measured by the number of positive blocks. A significant difference in diagnosed by digital imaging, serum prostate specific antigen, and needle biopsy. Gleason score, location, and volume are unknown tumor features. Result: Gleason score, tumor volume, and laterality between needle biopsy and prostatectomy materials Gleason score and tumor volume enhanced concordance. Conclusion: For a prostate cancer diagnosis, a digital exam, serum PSA and needle biopsy are quite sensitive. Lesser known tumor characteristics include Gleason score, location, and volume.