Indus offshore basin of Pakistan is a prolific region for hydrocarbon resource exploration, however along with the availability of limited geological and geophysical data, an attempt has been carried out in this area. Data from a seismic strike line 9033-86 which contains shot points 1481 to 3361 have been considered comprehensively with remarkable and incredible calibration. Seismic interpretation techniques were used to understand five important reflectors the Upper Cretaceous, Eocene, Lower and Upper Oligocene, and Intra Miocene successions. Structurally, the area comprises of normal faults i.e., horst and graben structures on the seismic profiles. Three normal faults have been recognized in the region, which reflects the extensional regime and associated structural styles. Through analysis of vertical and lateral velocity variations of various geological layers, interval velocity and average velocity graphs have been prepared from the concerned velocity functions. According to the time-depth conversion model, depth contour maps outline the Eocene units with anticline and syncline. The trend of these reflectors shows that these are more or less parallel to each other while dipping towards the northwest which may provide a suitable structure for the accumulation of hydrocarbons. Therefore, an integrated study of accurate seismic interpretation, structural analysis and time-depth conversion provided a promising site for future hydrocarbon exploration.