Objective: To assess the relationship between radiological findings and laboratory parameters, for safe and timely management of COVID-19 disease patients. Study Design: Retrospective observational study. Place and Duration of Study: The study was conducted at COVID-19 isolation ward of Frontier Corps Hospital Quetta, from April 15th to June 30th, 2020. Materials and Methods: Suspected COVID-19 (on the basis of history) patients, from April 15th to June 30th, 2020, were included in the study. Laboratory parameters including, Neutrophils, Lymphocytes, C-Reactive Protein (CRP) were retrospectively collected from medical records. Severity of lung changes on high resolution chest CT was scored according to the lung involvement (CO-RADS score 1-6). Spearman rank correlation was used to evaluate the relationship between CO-RADS score and laboratory parameters. Results: A total of 50 patients (mean age 34.7+6.46 years [standard deviation]; age range, 23-49 years) were evaluated. The patients underwent a total of 150 CT scans chest. CO-RADS was significantly co-related with neutrophils count at day 1 (r=0.93, p-value < 0.001), day 5 (r=0.47, p-value=0.001), day 14 (r=0.94, pvalue<0.001), lymphocytes count at day 1 (r=0.15, p-value<0.001), day 5 (r=0.90, p-value<0.001), day 14 (r=0.83, p-value=0.004), CRP at day 1 (r=0.90, p-value=0.001), day 5 (r=0.36, p-value=0.011) and at day 14 (r=0.93, p-value=0.001). Conclusion: The results of this study showed that the severity of lung involvement on high resolution CT (HRCT) chest positively correlate with laboratory parameters. The study provides an insight into the appropriate interval of chest CT to reduce radiation and promote timely management of COVID-19 patients.