Drug Induced hepatotoxicity is a common occurrence and one of the main reasons of drug withdrawal from the market after approval by a Federal Agency such as the FDA. `file cause of hepatic injury can also be bacterial parasitic or viral. Although the liver has a very high regenerative potential compared to other organs, acute liver failure has a high mortality rate. The drug-induced or other forms of liver damage such as viral hepatitis can also lead to long lasting chronic effects such as fibrosis resulting in cirrhosis or hepatocellular carcinoma. The mechanism of liver damage due to chemicals such as Paracetamol (Acetaminophen) or other agents such as viruses is complex and only partly understood. It appears that free radical injury is involved in liver damage although other mechanisms have also been described. At present there is no treatment for acute Hepatic failure and only supportive treatment is available. Viral hepatitis is also a major cause of morbidity and mortality in this part of the world. There is a vaccine available for Hepatitis B but it also provides only partial safety. The reason for being expensive is because it is made by Recombinant DNA Technology. The extracts of Withania somnifera have a very long history of use in traditional medicine such as the Ayurvedic system for more than 3000 years. The active ingredients of this plant are withanolides,which are steroidal lactones, have been shown to have adaptogenic and regenerative properties. The powdered roots of Withania somnifera showed curative property in the context of carbendazim-induced histopathological changes in the liver and kidney of rat. (Akbarsha, et al. (2000). In this review article, we will mention some Hepatoprotective natural compounds that are used in different parts of the world.