Tuberculosis is a health hazard for the third world countries, it poses a global challenge for control & prevention of resistance, mortality & morbidity. 90 patients completed the DOTS programme, 52 were females and 38 males, the mean age was 37.5±5.6 years. 60% of the patients had asymptomatic increase in the level of ALT, and AST, elevation was >2ULN in 23.33% and >3ULN in 14.44% and >5ULN in 2.22% of the cases 2.22 % also had elevated serum bilirubin levels.