Background: Self-directed learning is the quality of student in which they acquire their own requirements refer to their curriculum and owns the capability to study and improve their information, ability and behavior fulfilling the demands of medical profession. Readiness of self-directed is the degree to which the student possesses this ability to control over the quality of self-directed learning. Aim: To identify self-directed readiness among students and also to compare the self-directed learning readiness between students of traditional and integrated modular curriculum. Methodology: Current study was cross-sectional quantitative study among students of 1st year and 4th year MBBS in University College of Medicine and Dentistry, The University of Lahore. Pre-validated Questionnaire Self Directed Learning Readiness Scale (SDLRS) were used to check level of readiness of Self-Directed Learning among students of 1st year and 4th year. Data obtained was interpreted by using SPSS version 21. T-test was applied to compare the difference among the mean score of both the classes. Results: Significant difference between Readiness of Self-Directed Learning among modular system and traditional system. P value is 0.004 (significant value <0.05) (95% confidence interval) which shows high readiness of Self-Directed Learning among students of 1st year than 4th year. Conclusion: In this study, it was revealed that in spite of high level of maturity and experience of 4th year students, readiness of self-directed learning is more amongst students of 1st year MBBS students.