Typhoid fever is a bacterial infection caused by Salmonella typhi or S. paratyphi, recognized as a classical cause of fever in returning travellers. However, its neuro-psychiatric presentations are rarely reported in travellers diagnosed in western countries, whereas they are more commonly described in patients treated in endemic areas. We report an interesting case of encephalitis in enteric fever at a tertiary care hospital in Karachi, Pakistan. Case Report: We present an interesting and unusual case of a 22 year old female, married with no known comorbid, no travelling history, came to emergency with fever for 15 days and altered level of consciousness along with generalised stif ness and frothing from mouth. All relevant baselines investigations were done, multi-disciplinary teams were taken on board, blood cultures reported salmonella typhi and thus she was being managed on the lines of enteric encephalitis.