Inflammatory mediators released in pulmonary tuberculosis enhance hyper-coagulable states: a crucial role of tissue factor

Aza Mustafa; Elharam Ibrahim Abdallah Dafaallah; Alaa Eltayeb Omer; Abdel Rahim Mahmoud Muddathir; Altaf Ali Mangi; Lienda Bashier Eltayeb

doi:10.3923/pjbs.2022.725.731

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Inflammatory mediators released in pulmonary tuberculosis enhance hyper-coagulable states: a crucial role of tissue factor

Author(s)

Aza Mustafa Department of Hematology and Blood Transfusion, Faculty of Medical Laboratory Sciences,University of Alzaiem Al-azhari, Khartoum, Sudan

Elharam Ibrahim Abdallah Dafaallah Department of Hematology and Blood Transfusion, Faculty of Medical Laboratory Sciences, University of Alzaiem Al-azhari, Khartoum, Sudan

Alaa Eltayeb Omer Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj-Riyadh, Saudi Arabia

Abdel Rahim Mahmoud Muddathir Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences Taibah University,Medina, Kingdom of Saudi Arabia

Altaf Ali Mangi Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan

Lienda Bashier Eltayeb Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj-Riyadh, Saudi Arabia

Abstract

28 Background and Objective: Immune complexes and pro-inflammatory cytokines deduced from communicable diseases have been manifested to induce pro coagulopathy and tissue factor (TF) assertion in macrophages and the endothelial cells that remain at critical risk in tuberculosis (TB) patients. The current study was carried out among Sudanese patients with Pulmonary tuberculosis aimed to determine the long-term impacts of Tb infection on the coagulation cascade. Materials and Methods: A cross-sectional study was conducted among 30 patients who are already diagnosed with tuberculosis compared with the control group. Pulmonary Tuberculosis diagnosis of cases was emphasized in accordance with clinical examination, chest X-ray and positive Ziehl-Neelsen (ZN) smear. The questionnaire was used for the collection of demographic and baseline data. About 2.5 mL of venous blood was collected in trisodium citrate containers and 2.5 mL of blood was collected in EDTA container. SPSS version 21 statistical software was used for statistical analysis. Results: PLT count showed a significant difference (p = 0.03) with a mean (329.20×103 and 287.60×103 µLG1) among patients and control, respectively. APPT shows a significant difference (p = 0.00), Mean of PLT decreased as the disease progressed (336.20±36.02, 345.43±16.02, 511.04±42.02) showed a significant correlation between PLT count of test and duration of disease (p = 0.00). Additionally, a significant correlation between PLT count, MPV and APTT and the status of the patient’s drug resistance was revealed (p<0.02, 0.01 and 0.02). Conclusion: There is a significant alteration in coagulation parameters (PT, APTT and platelets count) among Sudanese pulmonary tuberculosis patients, which may indicate a feature of a hypercoagulable state.

Publication Details

Page(s) 725-731

DOI 10.3923/pjbs.2022.725.731

Published Journal: Pakistan Journal of Biological Sciences, Volume: 25, Issue: 8, Year: 2022

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Keywords

pulmonary tuberculosis, inflammation, coagulation factors, hypercoagulable, tissue factor

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