Objective: To assess the complications of Modified Radical Neck Dissection in thyroid Malignancy. Study Design: Cross-sectional descriptive study Place and Duration of Study: This study was conducted at the Department of Surgery, Jinnah Postgraduate Medical Centre, Karachi from April 2011 to April 2021. Materials and Methods: A total of 198 cases of thyroid malignancies treated with modified radical neck dissection surgery were included. Type of Thyroid malignancy was classified as papillary carcinoma, follicular carcinoma, and medullary carcinoma. Surgeries carried out were classified as isolated MRND, thyroidectomy with MRND and completion thyroidectomy with MRND. Outcome of MRND was assessed by complications which were recorded as transient hypocalcemia, permanent hypocalcemia, temporary change in voice, permanent hoarseness, wound infection, seroma formation, and thoracic duct injury. Results: Out of 198 cases 135 were females with mean age of presentation of 41years and males were 47 with mean age of 46years. Female to male ratio was nearly 2:1. Papillary carcinoma was found in 165 (84.1%) cases, Medullary carcinoma in 19 (9.7%) cases, and follicular carcinoma in 14(5.6%). Isolated MRND was performed in 33 (16.7%) cases, total thyroidectomy with MRND in 87(43.9%) cases and completion thyroidectomy with MRND in 78(39.4) cases. Most common postoperative complication was found to be transient hypocalcemia in 16 (8.1%) cases followed by seroma formation and wound infection. Conclusion: MRND is a safe procedure with low rate of complications when performed by experienced and skilled surgeon in a dedicated endocrine surgery unit.