Glucagonoma syndrome.

Muhammad Ishaq; Riaz Ali Khan; Ghulam Mujtaba

Author(s)

Muhammad Ishaq Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan

Riaz Ali Khan Nishtar Medical College and Hospital, Multan, Pakistan

Ghulam Mujtaba Department of Dermatology, Nishtar Medical College, Multan, Pakistan

Abstract

Glucagonoma syndrome is a rare disease in which necrolytic migratory erythema is often one of the early symptoms. Weight loss and diabetes mellitus are two other characteristics of this syndrome. Necrolytic migratory erythema is typically characterized on skin biopsies by necrolysis of upper epidermis with vacuolated keratinocytes. Persistent hyperglucagonemia Results: in excessive stimulation of basic metabolic pathway which in turn Results: in diabetes mellitus at the expense of tissue glycogen stores. Deficiencies of various essential nutrients and vitamin B lead to dermatosis. Due to rarity of glucagonoma, it is quite difficult to diagnose this syndrome at early stages. This is a review article.

Publication Details

Page(s) 106-108

DOI DOI not available

Published Journal: Journal of Pakistan Association of Dermatologists, Volume: 19, Issue: 2, Year: 2009

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