Eleven compounds have been isolated for the first time from Aerva persica namely, β-sitosterol (1), 4-hydroxybenzaldehyde (2), 4-hydroxybenzoic acid (3), 5,7-dimethoxycoumarin (4), 5,8-dihydroxycoumarin (5), 5,6,7-trimethoxycoumarin (6), 4-hydroxy-3,5-dimethoxybenzaldehyde (7), 3,4`-dihydroxy-3`,5`-dimethoxypropiophenone (8), gallic acid (9), 5-hydroxy-3`,4`,6,7,8-pentamethoxyflavon (10) and β-sitosterol 3-O-β-D-glucopyranoside (11), respectively. Their structures have been elucidated by EIMS, HREIMS, FAB, HRFABMS and NMR spectroscopic data.