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Inter-observer variability in gleason scoring system for histological grading of adenocarcinoma prostate

Author(s)
Farah Ahsan Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Ahmed Ahson Khan Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Asif Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Maria Aslam Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
Saba Hamayun Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
Hafeez-Ud-Din Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
Abstract
Objective: To compare the variability between observers while grading adeno carcinoma prostate when using the Gleason scoring system and checking its reproducibility between the observers. Study Design: Prospective double-blind study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Jan to Jul 2020. Methodology: A total of 128 specimens of adeno carcinoma of prostate were collected and evaluated again by using modification by Epstein of the Gleason system done in 2005.Two pathologists performed the assessment of the specimens by the double-blind method. The level of similarity overlaps or concordance between both the pathologists was calculated using the kappa co-efficient. Results: The level of concordance among the two pathologists for Gleason pattern sums stood at 67% (0.556, 95% CI 0.40-0.59), respectively. The highest level of concordance was observed at Gleason sum score of 7 in 30 samples (23.4%) Conclusion: There was a moderate level of concordance in the assessment of the two pathologists by using the Gleason sum score system. It can be greatly improved if better trained uropathologists employ the Gleason scoring system resulting in less variability and more conformity.
Publication Details
Page(s) 327-330
DOI 10.51253/pafmj.v72i1.7776
Published Journal: Pakistan Armed Forces Medical Journal, Volume: 72, Issue: 1, Year: 2022

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Keywords
Gleason scoring, Inter-observer variability, Prostate cancer.
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