This study focuses on the changes in environmental resources in the last three decades in the coastal districts of Sindh through evaluation of the Normalized Difference Vegetation Index (NDVI), the Normalized Difference Water Index (NDWI), and the area of fresh water bodies. District Badin is the most affected district in terms of decline in vegetation cover as compared to Thatta and Sujawal. In district Badin, the NDVI value has been reduced due to the maximum reduction (19.55%) of dense vegetation from 1990 to 2000. Changes in NDVI in districts Thatta showed slightly increased values for dense vegetation (2.85%) and decreased sparse vegetation (10.86%). In Sujawal, the NDVI values for dense vegetation increased (5.19%) and decreased sparse vegetation (5.12%), especially during 2010 to 2020. Moreover, there is an increasing trend in water bodies during 1990 to 2020 in Sujawal. During this period, a minor reduction in moisture and vegetation land cover was observed. However, a reduction in moisture and vegetation cover was noticed in other districts with a swift increment in NDWI possibly due to climate change in the area that is accountable for the proliferation of seawater intrusion. In Badin, the total area of Pateji Lake and Nareri lagoon has been drastically reduced during 1990 to 2020. Similarly, the overall area of fresh water bodies has also been reduced in Thatta and Sujawal.