Synthesis of Dihydroxamic Acids from Dinitrones, Structural Characterization and Antimicrobial Activities

Cherifa Mahieddine; Said Zerkout; Sidali Rayane; Houssam Boulebd; Affaf Laassami; Salah Akkal

Cherifa Mahieddine Département de chimie, Ecole Normale Supérieure de Kouba, B.P. 92, 16050 Vieux Kouba, Alger, Algérie; Laboratoire d’Etude et de Développement des Techniques de Traitement et d’Epuration des Eaux et de

Said Zerkout Département de chimie, Ecole Normale Supérieure de Kouba, B.P. 92, 16050 Vieux Kouba, Alger, Algérie

Sidali Rayane Laboratoire de Recherche en Didactique des Sciences, Ecole Normale Supérieure de Kouba, B.P. 92, 16050 Vieux Kouba, Alger, Algérie.

Houssam Boulebd Laboratoire de Synthèses de Molécules d’Intérêts Biologique, Université Mentouri de Constantine 1, Constantine, Algérie.

Affaf Laassami Laboratoire de Biologie Des Système microbiens, Ecole Normale Supérieure de Kouba, B.P. 92, 16050 Vieux Kouba, Alger, Algérie.

Salah Akkal Unit for the Valorization of Natural Resources, Bioactive Molecules and Physico-Chemical and Biological Analyzes, Faculty of Exact Sciences, Department of Chemistry, Mentouri University of Constantine 1- Route de Aïn El Bey, 25000, Constantine, Algeria.

The benefits of dinitrones (N,N'-Diphenyl-2,5-thenylenedinitrone, N,N'-Dimethyl-1,4phenylenedinitrone and N,N'-Dibenzyl-1,4-phenylenedinitrone) in the synthesis were chosen as simple process for synthesis of the purified dihydroxamic acid compounds in a shorter time with a good yield and high purity without need to purification. The most stable conformers of the synthesized compounds and their electronic properties have been determined using DFT/B3LYP calculations. Antimicrobial activity assessment of dihydroxamic acids showed their good efficiency.