Tranexamic Acid For Seroma Reduction

Surrendar Dawani; Hassan Ahmed; Salman Jafferi; Shahid Rasul

doi:10.21699/jsp.26.3.8

Author(s)

Surrendar Dawani Department of Surgery Unit IV, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Hassan Ahmed Department of Surgery Unit IV, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Salman Jafferi Department of Surgery Unit IV, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Shahid Rasul Department of Surgery Unit IV, Jinnah Postgraduate Medical Centre, Karachi, Pakistan

Abstract

Objective To compare the safety and effectiveness of tranexamic acid in reducing postoperative seroma formation in ventral hernia repair. Study design Comparative study Place & Duration of study Department of Surgery Ward 21 Unit IV, Jinnah Postgraduate Medical Centre (JPMC) Karachi, from July 2019 to February 2020. Methodology Patients with ventral abdominal hernia were included in the study. Study was approved by institution review board. A detailed history and clinical examination were done and routine biochemical investigations requested. Patients were operated after informed consent. Standard Onlay mesh repair was performed. Patients were divided into study and control groups. Tranexamic acid was given postoperatively to study group till 5th postoperative day (POD). Drains were placed under the skin flaps to record the volume of seroma after surgery. The outcome was assessed by comparing the volume of seroma postoperatively in both the groups. Results Sixty patients were enrolled with female to male ratio of 3:1. Mean age of the patients was 41.67±9.76 year. Twenty-one (35%) patients were <35 years of age. Mean volume of seroma formation in postoperative period in study group was 74.00+35.92 ml versus 130.00±055.96 ml in control group, which was highly significant (p= 0.001). Patients were stratified according to age and gender which showed no significant difference in relation to these variables. Conclusion Tranexamic acid is effective in reducing the volume of seroma postoperatively in patients with ventral hernia repair.

Publication Details

Page(s) 117-120

DOI 10.21699/jsp.26.3.8

Published Journal: Journal of Surgery Pakistan, Volume: 26, Issue: 3, Year: 2021

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Keywords

Tranexamic acid, Fibrinolysis, Seroma., Plasminogen