No Detail Found!

C-kit Expression in Oral Leukoplakia

Author(s)
Anand S. Tegginamani Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia
Vanishree H. Shivakumar Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia
Siti Mazlipah B. Ismail Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
Mannil T. Abraham Department of Dentistry, Sentosa Specialist Hospital, Taman Sentosa Perdana, Klang, Selangor, Malaysia
Bennete A. Fernandes Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia
Ahmad Termizi B. Zamzuri Faculty of Dentistry, SEGi University, Kota Damansara, Petaling Jaya, Selangor, Malaysia
Abstract
Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia s malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to di erentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required.
Publication Details
Page(s) 256-258
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 2, Year: 2022

Request the full text from PASTIC

Keywords
Risk prediction, Disease progression, Oral leukoplakia, CD 117, Oral dysplasia
More from Journal of College of Physicians and Surgeons--Pakistan : JCPSP
0

Citations

0

Downloads

61

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk