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Subcutaneous leiomyosarcoma in a smad3+/- mouse.

Author(s)
Sang-Hyeob Kim Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Ae-Ri Ji Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Jin-Kyu Park Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Ah-Young Kim Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Eun-Mi Lee Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Eun-Joo Lee Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Chang-Woo Min Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Kyung-Ku Kang Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Myeong-Mi Lee Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Soo-Eun Sung Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Meeyul Hwang Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Dong-Mi Kwak Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Tae-Hwan Kim Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Kyu-Shik Jeong Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Abstract
Subcutaneous leiomyosarcoma is a malignant tumor that originates from smooth muscles in the skin. Herein, we report a case of subcutaneous leiomyosarcoma that occurred in the ear pinna of a 19-month-old male Smad3+/- mouse. On gross examination, the mass extended to the whole ear auricle and obscured the ear opening. The tumor was approximately 10x10 mm in size, ill-circumscribed, and firm with superficial hemorrhage. The cut surface of the mass was grayish-white and solid with focal necrosis and hemorrhage. Histologically, spindle tumor cells with cigar-like nuclei and plump cells with round nuclei formed broad interlacing fascicles. Additionally, the tumor cells invaded adjacent muscles. Immunohistochemically, the tumor sections had positive reactions for desmine and a-SMA and were partially positive for vimentin while negative for S-100 and myogenin. Based on the results of the examination, we diagnosed this case as subcutaneous leiomyosarcoma.
Publication Details
Page(s) 420-422
DOI DOI not available
Published Journal: Pakistan Veterinary Journal, Volume: 34, Issue: 3, Year: 2014

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