In majority of cases, anesthesia is a routine procedure, following well-established protocols, but in some patients with rare diseases there are additional challenges for the clinical anesthesiologist. Pain is a defense mechanism that expresses damage or deterioration of the body. The body protects itself from noxious stimuli resulting from this sensation. This mechanism is broken in Congenital Insensitivity to Pain and Anhidrosis (CIPA), which is a rare autosomal recessive disorder characterized mainly by the lack of reaction to these stimuli.