Objective: To explore the attitude of postgraduate medical and dental residents about research work and to identify barriers in the way of research activities. Methodology: The cross-sectional study was conducted from May to July, 2018, at three public-sector medical and dental institutions in Quetta, the capital of Pakistan province of Balochistan, and comprised postgraduate residents. Data was collected using a pre-validated 16-item Likert scale questionnaire. Data was analysed using SPSS 23. Results: Of the 72 subjects, 44(61.1%) were males. The overall mean age was 23.3±4.6 years (range: 2830 years. The residents demonstrated willingness to conduct clinical research with a mean score of 4.36±0.65. There was no association of attitudes and barriers with socio-demographic and personal characteristics (p>0.05). Deficient lab facilities (p-<0.001), and inaccessibility to electronic and hospital data (p=0.003) were the major factors identified as research barriers. Conclusion: Barriers to research need to be addressed in designing research curricula to encourage and facilitate meaningful research.