Ovarian Sertoli cell tumours: practical points

Ancuta-Augustina Gheorghisan-Galateanu; Mara Carsote; Dana Terzea; Ana Valea; Adina Ghemigian

Author(s)

Ancuta-Augustina Gheorghisan-Galateanu Department of Cellular and Molecular Biology, Carol Davila University of Medicine and harmacy, Bucharest, Romania

Mara Carsote Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Dana Terzea Onco Team, Monza Hospital, Bucharest, Romania

Ana Valea Department of Endocrinology & Clinical County Hospital, I.Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Adina Ghemigian Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Abstract

Rarity of Sertoli cell tumours contributes to a low index of suspicion and therefore a thorough knowledge of the clinicopathological and immunological characteristics of such tumours is essential to diagnosis and proper management of the treatment and follow-up. The current narrative review of literature was planned to focus on ovarian Sertoli cell tumours that arise from the sex cords cells, which are typically benign unilateral neoplasia incidentally detected, or associated with hormonal hyperactivity, in women of reproductive age. A priory unpublished case of a 35-year old female is also introduced as the base of discussion Abdominal massrelated syndrome and vaginal bleeding anomalies have been reported. Genetic background, if presented, is mostly related to Peutz-Jeghers syndrome caused by STK11/LKB1 mutation. The tumour displays a microscopic tubular pattern and rarely displays cords or trabecular, retiform, spindles, diffuse or areolar structures. Although immunohistochemistry can be helpful in establishing the diagnosis, the results are sometimes inconclusive and the current results require new research to establish a specific immunological panel.

Publication Details

Page(s) 129-133

DOI DOI not available

Published Journal: Journal of Pakistan Medical Association, Volume: 70, Issue: 1, Year: 2020

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Keywords

Immunohistochemistry., Histology diagnosis, Ovarian Sertoli cell tumour, Sex cord tumour