Development and evaluation of a cream containing solid lipid nanoparticles loaded with Vitamin E

Fasiha Shah; Omar Sarheed; Shahnaz Usman; Qamar ul Islam

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Development and evaluation of a cream containing solid lipid nanoparticles loaded with Vitamin E

Author(s)

Fasiha Shah Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University,Ras al Khaimah, UAE,

Omar Sarheed Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University,Ras al Khaimah, UAE,

Shahnaz Usman Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University,Ras al Khaimah, UAE,

Qamar ul Islam Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University,Ras al Khaimah, UAE,

Abstract

Solid lipid nanoparticles (SLNs) have several potential applications in the topical drug delivery. The current project aimed to prepare and characterize SLNs loaded with vitamin E for topical administration and incorporating the prepared SLNs in a cream base. Further, the permeation of prepared SLNs was studied through a synthetic membrane and the release profiles were compared with vitamin E cream. The prepared SLNs were subjected to stability studies at two different temperatures. Hot homogenization followed by dilution technique was used for the preparation of SLNs. In this project, PDMS membrane was used to mimic the skin for permeation studies. From the results of this study, it can be concluded that prepared SLNs had enhanced the permeation of vitamin E as compared to vitamin E cream.

Publication Details

Page(s) 2109-2119

DOI DOI not available

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 34, Issue: 6, Year: 2021

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Keywords

Vitamin E, Solid lipid nano particles, PDMS, skin permeation

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