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A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation

Author(s)
Hany SM Ali Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, KSA; Pharmaceutics Department, Faculty of Pharmacy, Assiut University, Egypt
Shahzeb Khan Department of Pharmacy, University of Malakand,Dir Lower, KPK,Pakistan
Peter York Institute of Life Sciences, University of Bradford,BD7 1DP,UK
Syed Mukarram Shah Department of Pharmacy, University of Sawabi KPK,Pakistan
Jahangir Khan Department of Pharmacy, University of Malakand,Dir Lower, KPK,Pakistan
Zahid Hussain Department of Pharmaceutics, Faculty of Pharmacy, University Teknologi Mara, Puncak Alam Campus,Malaysia
Barkat Ali Khan Department of Pharmaceutics, Faculty of Pharmacy, Gomal University D.I Khan,KPK,Pakistan
Abstract
Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to have a rod shape with a narrow particle size distribution (PDI =0.17). Results of differential scanning calorimetry and X-ray diffraction analyses revealed minor modifications of crystallinity of hydrocortisone following the milling process. Solubility of hydrocortisone was enhanced by nanonization to 875µg/ml ±2.5, an almost 2.9-fold compared to the raw hydrocortisone. Moreover, the nanosuspension formulation substabtially enhanced the dissolution rate of hydrocortisone where >97% of the hydrocortisone was dissolved within 10 minutes opposed to 22.3% for the raw 50% for the raw hydrocortisone and the commercial tablet, respectively. The bioavailability study resulted in AUC 0-9h for HC nanosuspensions (31.50±2.50), which is significantly (p<0.05) higher compared to the AUC 0-9h (14.85±3.25) resulted for HC solution. The nanosuspension was physically stable at room temperature for 24 months.
Publication Details
Page(s) 1635-1643
DOI DOI not available
Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 30, Issue: 5, Year: 2017

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Keywords
dissolution, stability, Nanosuspension, Milling, solubility, Hydrocortisone
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