Van Wyk Grumbach Syndrome

Maira Riaz; Mohsina Noor Ibrahim; Taj Muhammad Laghari; Misbah Iqbal Hanif; Jamal Raza

Author(s)

Maira Riaz Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan

Mohsina Noor Ibrahim Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan

Taj Muhammad Laghari Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan

Misbah Iqbal Hanif Department of Paediatrics, National Institute of Child Health,Karachi,Pakistan

Jamal Raza Department of Paediatrics, National Institute of Child Health,Karachi,Pakistanof Paediatrics, National Institute of Child Health,Karachi,Pakistan

Abstract

Van Wyk Grumbach syndrome is well known for protracted hypothyroidism, characterised by multicystic ovaries (normal size ovaries contain many follicles of various sizes), isosexual precocious puberty and delayed skeletal growth. A series of ten children with Van Wyk Grumbach syndrome is been presented with their clinical features, biochemical and radiological pro le and management. Patients showed a noteworthy improvement upon thyroxine therapy. It is vital to keep this entity in consideration and; hence, should investigate for thyroid status during the evaluation of ovarian cysts. Thyroxin replacement after establishing the diagnosis early can prevent the patient from going through extensive workup and surgeries.

Publication Details

Page(s) 1332-1334

DOI DOI not available

Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 30, Issue: 12, Year: 2020

Request the full text from PASTIC

Keywords

Multicystic ovaries, Isosexual precocious puberty, Hypothyrodism