Objective: To find the association between hyperuricemia and ischemic stroke. Study Design: Case-control study. Place and Duration of Study: Departments of Medicine and Neurology, Mayo Hospital, Lahore, from October 2015 to September 2016. Methodology: A total of 100 patients were recruited in the study. Fifty cases were of acute ischemic stroke and fty were age- and gender-matched healthy controls. Serum uric acid level was estimted by photometry method at the time of admission. Hyperuricemia was de ned as the serum uric acid level of more than 6 mg/dl. Results: Mean serum uric acid levels in cases and controls were 5.996 ±1.99 mg/dl and 5.042 ±0.91 mg/dl, respectively. Hyperuricemia was present in 23 (46%) patients with ischemic stroke and in 10 (20%) controls. Among ischemic stroke patients, the frequency of hyperuricemia was signi cantly higher than in controls (p-value =0.006, Odds Ratio (OR) =3.41.) Conclusion: Serum uric acid was found signi cantly elevated in ischemic stroke patientsversus controls with 3.41 times more risk of having hyperuricemia in ischemic stroke patients.