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CRISPR Cas System: An efficient tool for cancer modelling

Author(s)
Mehran Akhtar Department of Biotechnology, Quaid-e-Azam University,Islamabad,Pakistan
Tazkira Jamal Department of Biotechnology, Quaid-e-Azam University,Islamabad,Pakistan
Mudassir Khan Department of Health Care Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Science and Technology,Islamabad,Pakistan
Shah Rukh Khan Department of Biotechnology, Quaid-e-Azam University,Islamabad,Pakistan
Shohra Haider Department of Biotechnology, Quaid-e-Azam University,Islamabad,Pakistan
Fazal Jalil Department of Biotechnology, Quaid-e-Azam University,Islamabad,Pakistan
Abstract
The Clustered Regularly Interspaced Short Palindromic Repeats-Cas-9 (CRISPR-Cas9) system has been a revolutionising tool in the field of molecular genetics, which provides a versatile range of editing potentials. Researchers can produce breaks or alter genomes with ease using the system. Cancer is one of the multi-gene diseases whose genes need to be studied in detail. The CRISPR-Cas9 technology may also provide a promising potential in the field of cancer genetics. The current narrative review comprised 50 research articles which were keenly analysed and the applications and outcomes of CRISPR-Cas9 system in cancer genetics were comprehensively and critically discussed. It was concluded that application of the system had great potential to help understand cancer biology of various types and could be used for its genetic modelling. However, much work is still needed to be done to apply the technology for understanding the mechanism of cancers and to help in the designing of appropriate therapies.
Publication Details
Page(s) 718-724
DOI DOI not available
Published Journal: Journal of Pakistan Medical Association, Volume: 71, Issue: 2B, Year: 2021

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Keywords
cancer, Cancer modelling, Cancer genetics, CRISPR-Cas9
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