No Detail Found!

Correlation between Circulating Tumor Cells and Plasma D-dimer and Clinicopathological Characteristics of Patients with Non-small Cell Lung Cancer

Author(s)
Junfu Wang Department of Thoracic Surgery, School of Medicine, Weifang Medical University, Jinan Central Hospital Affiliated to Shandong University,Shandong,China
Haibo Liu Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University,Jinan, Shandong,China
Xiaoming Sun Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University,Jinan, Shandong,China
Qiaoling Liu Department of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University,Jinan, Shandong,China
Shuyi Han Department of Central Laboratory, Jinan Central Hospital Affiliated to Shandong University,Jinan, Shandong,China
Liangming Zhu Department of Thoracic Surgery, School of Medicine, Shandong University, Jinan Central Hospital Affiliated to Shandong University,Jinan, Shandong,China
Abstract
Objective: To study the relationship between circulating tumor cells (CTCs) and plasma D-dimer (D-D) and their correlation with clinicopathological characteristics of patients with non-small cell lung cancer (NSCLC). Study Design: A descriptive study. Place and Duration of Study: Department of Thoracic Surgery, Jinan Central Hospital A liated to Shandong University, Jinan, Shandong, China, from December 2015 to August 2019. Methodology: Seventy- ve patients with NSCLC were selected as the research subjects. The contents of CTCs and D-D were determined and the results were analysed as per objective. Data was analysed quantitatively, using SPSS Version 24.0. Results: Forty- ve patients with NSCLC were positive for CTCs. The level of D-D in NSCLC patients was signi cantly increased. The D-D level in CTCs-positive patients was 0.79 (0.43-1.80) mg/L. The levels of CTCs and D-D in NSCLC patients were not a ected by gender and pathological subtypes and other factors (p>0.05). CTCs and D-D in peripheral blood of NSCLC patients were signi cantly correlated with the total stage of lung cancer patients (p <0.05). Conclusion: The levels of CTCs and D-D in peripheral blood of NSCLC patients are signi cantly correlated with clinicopathological features, and the positive CTCs and high levels of D-D may indicate the late stage of the disease and poor prognosis, and there is a correlation between the two. The combined detection of the two is of great signi cance in predicting the progress and poor prognosis of NSCLC patients, and can guide the clinical diagnosis and treatment.
Publication Details
Page(s) 417-421
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 31, Issue: 4, Year: 2021

Request the full text from PASTIC

Keywords
Clinicopathologic features, Non-small cell lung cancer (NSCLC), D-dimer (D-D), Circulating tumor cells (CTCs)
More from Journal of College of Physicians and Surgeons--Pakistan : JCPSP
0

Citations

0

Downloads

70

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk