Pattern of Haemoglobin Disorders

Samina Amanat; Nadeem Ikram; Haider Zaigham Baqai

Author(s)

Samina Amanat Department of Pathology, Pakistan Atomic Energy Commission Hospital, Islamabad, Pakistan

Nadeem Ikram Department of Pathology, Pakistan Atomic Energy Commission Hospital, Islamabad, Pakistan

Haider Zaigham Baqai Department of Pathology, Pakistan Atomic Energy Commission Hospital, Islamabad, Pakistan

Abstract

Background: To study the pattern of different haemoglobin disorders in our set up. Methods: In this descriptive study, patients referred for haemoglobin electrophoresis were included. Detailed clinical history was taken. Physical findings were noted. Peripheral blood film and haemoglobin electrophoresis was performed . Results: Out of total 666 referred cases , 176 (26.4%) were detected to have abnormal haemoglobin. The commonest disorder was beta thalassaemia trait (13.2%). Beta thalassaemia major was found in 9.9 % cases. Other haemoglobin disorders like HbD,HbE, and HbS alone or in combination with beta thalassaemia were detected in 2.95% cases. One case of beta thalassaemia minor revealed normal pattern on haemoglobin electrophoresis and was diagnosed on molecular studies Conclusion: The increased trend of haemoglobin electrophoresis employment predicts a decline in homozygous states of autosomal recessive haemoglobin disorders

Publication Details

Page(s) 15-18

DOI DOI not available

Published Journal: Journal of Rawalpindi Medical College, Volume: 16, Issue: 1, Year: 2012

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Keywords

Haemoglobin disorders.Haemoglobin