Thyroid hormones might be able to regulate the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX) enzymes. The role of thyroid hormones in metabolic pathways and antioxidant enzyme activities are well known in many species. Nevertheless, there is no report describing probable relationship between thyroid hormones status, erythrocyte antioxidant enzymes and serum profiles of trace elements. This study was undertaken to investigate the relationship between these parameters in Iranian native goats. Blood samples were taken from the jugular vein of 50 clinically healthy Iranian native goats under aseptic conditions during 6 consecutive days of summer. The serum was analyzed for serum profile of thyroid hormones, trace elements, SOD and GPX activity. There were no significant differences in serum thyroid hormones, serum levels of zinc (Zn), copper (Cu), manganese (Mn), iron (Fe), selenium (Se) and antioxidant enzymes on different days (P>0.05). There were significant correlations between triiodothyronine (T3) and GPX (P