OBJECTIVE: To find out the electrophysiological changes including pulse, blood pressure, Oxygen saturation and ECG after electroconvulsive therapy (ECT) under Propofol General Anaesthesia (GA). METHODS: Fifty patients with Depression who underwent ECT were studied. All patients were anesthetized using propofol. They were stratified according to electrophysiological changes including SPAO2, pulse and blood pressure at 60, 90 and 120 seconds after a course of 6 sessions of ECTs. Oxygen saturation was measured using a pulse oximeter. RESULTS: The age of the patients ranged from 18-60 years and mean age was 45±12.02.The ranges of oxygen saturations recorded before ECT was 96-100%. It was 94-97% at 60 sec, 90-92% at 90 sec, 95-98% at 120 seconds. There was initial decrease in diastolic pressure from pre - ECT (77±07) to 72±05 at 60 sec followed by increase of 73±05 at 90 sec and again coming to 74±05 at 120 sec, whereas in case of systolic pressure initial decrease of 117±06 at 60 sec, 114±04 at 90 sec and 116±07 at 120 sec. There was a decrease in mean pulse from 77±4.64 (pre - ECT) to 73±2.87 at 60 sec, 74±4.02 at 90 sec and maintaining at 74±3.52 at 120 sec after ECT procedure. Out of 50 patients, 3 (6%) developed bradycardia and 2 (4%) had ST-segment flattening at 60 seconds. CONCLUSION: ECT under Propofol is very safe modality of treatment for patients with depressive illness and it gives much better and stable hemodynamic changes with rapid recovery from anesthesia.