Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of heterogeneous etiology. It is characterized by rapid progression of painful necrolytic ulcer. It is associated with systemic diseases in at least 50% of patients. Diagnosis is made by exclusion of other causes of similar appearing cutaneous ulcerations including infections, malignancy, etc. In our case pyoderma gangrenosum was associated with ulcerative colitis.