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Development and validation of a RP-HPLC method for simultaneous estimation of naproxen and Ranitidinehydrochloride.

Author(s)
Tasnuva Haque Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka, Bangladesh
Kanij Fatema Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka, Bangladesh
Mesbah Uddin Talukder Department of Pharmacy, The University of Asia Pacific, Dhaka, Bangladesh
Susmita Laila Product Development Department, Bangladesh Limited, Tongi, Gazipur, Bangladesh
Abstract
A simple, specific and accurate reverse phase liquid chromatographic method has been developed for the simultaneous determination of naproxen and ranitidine HCl. Both the drugs are official with British Pharmacopoeia 2007, but do not involve simultaneous determination of naproxen and ranitidine HCl. The separation was carried out using 4.6×250 mm Symmetry Shield TM RP 18 with a particle diameter of 5 μm and mobile phase containing 0.1M orthophosphoric acid: methanol (35:65, pH 3.1) in isocratic mode. The flow rate was 1.00 ml/min and effluent was monitored at 240 nm. The retention times (average) of ranitidine HCl and naproxen were 2.36 min and 12.39 min, respectively. The linearity for naproxen and ranitidine HCl was in the range of 5-35 μg/ ml and 1.5-12 μg/ ml, respectively. The potencies of naproxen and ranitidine HCl were found 99.40 % and 99.48 %, respectively. The proposed method was validated and successfully applied to the estimation of naproxen and ranitidine HCl in newly formulated combined tablet and in plasma.
Publication Details
Page(s) 379-383
DOI DOI not available
Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 23, Issue: 4, Year: 2010

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