No Detail Found!

Interaction study between Levofloxacin and Omeprazole using urinary pharmacokinetic data

Author(s)
Chowdhury Farhana Faruquee Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
M. Ashikullah Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Seheli Parveen Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Abdul-Hasnat Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
M. Abul Kalam Azad Department of Pharmaceutical Technology, University of Dhaka, Dhaka, Bangladesh
M. Israt Rayhan Institute of Statistical Research and Training, University of Dhaka, Dhaka, Bangladesh
Abstract
The objective of this study was to observe the drug interaction between levofloxacin and omeprazole using urinary excretion data. Levofloxacin tablet and omeprazole capsule were administered separately as well as in combination in fasting condition with a wash out period of two weeks after each administration. Urine was collected at different time intervals of 0, 0-2, 2-4, 4-8, 8-12, 12-24, 24-36 and 36-48 hr post-dose and analyzed using a validated HPLC with UV detection. Different pharmacokinetic parameters for both drugs were determined using non-compartmental method. The maximum rate of excretion (Rmax) of levofloxacin was not decreased significantly when co-administered with omeprazole (p>0.05). Similarly no significant difference (p = 0.350) was observed for Rmax of omeprazole when co-administered with levofloxacin. Again the fraction of levofloxacin excreted (fe/f) was not changed significantly (p = 0.953) due to the co-administration of omeprazole. Similarly fraction of omeprazole excreted (fe/f) also remained unaffected (p = 0.672) when coadministered with levofloxacin. No significant change was observed for the area under the rate of excretion versus midpoint of time interval curve from zero to 48 hours (AURC0-48) for levofloxacin and omeprazole (p = 0.816 and 0.792 respectively) when administered separately and co-administered with each other. The study clearly revealed that levofloxacin and omeprazole do not undergo any kind of interactions when administered together. So it can be concluded that these two drugs can be prescribed together to achieve optimum therapeutic activity.
Publication Details
Page(s) 143-148
DOI DOI not available
Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 23, Issue: 2, Year: 2010

Request the full text from PASTIC

More from Pakistan Journal of Pharmaceutical Sciences
0

Citations

0

Downloads

30

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk